Motor functional scores correlated with tibialis anterior MUNIX. MUNIX variability in tibialis anterior (TA) correlated with CMAP variability. MUNIX variability was significantly higher in the SMA group than in the control group.
Compared to healthy controls, SMA patients showed significant reductions in MUNIX values among all muscles studied, whereas CMAP showed reductions only in the weaker muscles (abductor digiti minimi and tibialis anterior). Age-matched healthy controls (n = 20) were enrolled to obtain normative CMAP and MUNIX values from the same muscles. The patients underwent compound motor action potential (CMAP) and MUNIX studies of the right abductor pollicis brevis, abductor digiti minimi and tibialis anterior muscles. Twenty SMA patients (SMA types 3 and 4), aged between 7 and 41 years, were clinically evaluated through the Hammersmith Motor Functional Scale Expanded and the Spinal Muscular Atrophy-Functional Rating Scale.
The motor unit number index (MUNIX) is a biomarker used to assess loss of motor units in later-onset SMA patients. Spinal muscular atrophy (SMA) is a motor neuron disease associated with progressive muscle weakness and motor disability. The MUNIX technique, which accurately estimated lower motor neuron loss and the number of remaining functional motor units, was shown to be a useful electrophysiological biomarker for disease progression and a potential biomarker for treatment response.
The total CMAP amplitude correlated with the grasp and pinch scores (p<0.05), and the MUNIX measurements correlated with the MFM scores. The intraclass correlation coefficient was good for the intrarater variability of the CMAP amplitude, MUNIX, and MUSIX in the ADM (0.95, 0.83, and 0.89, respectively) and the APB (0.98, 0.96, and 0.94, respectively). In the patients with Ped-SMA, the MUNIX and compound muscle action potential (CMAP) amplitudes were significantly decreased and the motor size unit index (MUSIX) was significantly increased in the ADM and APB when compared to controls. The MUNIX technique was evaluated in the abductor digiti minimi (ADM) and abductor pollicis brevis (APB) on two sides when possible.
KAIRON RITCHEY MANUAL
Clinical examination included manual muscle testing, dynamometry (grasp and pinch), and motor function measure (MFM). This study evaluated the feasibility and the clinical relevance of using the MUNIX technique for patients with pediatric SMA (Ped-SMA) and correlated MUNIX results with clinical scores.įourteen patients with type II Ped-SMA (11 females median age 11 years ) and 14 controls (nine females median age 10.75 years ) were enrolled and matched by sex, age, height, weight, and body mass index. To view the current address, phone number, age, and associates of any adult in Jacksonville, FL simply click a name listed below.In adult spinal muscular atrophy (SMA), the motor unit number index (MUNIX) has been shown to be an useful electrophysiological biomarker. Select a Person in Jacksonville, FL to View Detailsīrowse the list of people in Jacksonville, FL below.